Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.

Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.

Blog Article

Inflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process.The role of neutrophil granulocytes as first Whiskey Decanter Set driver of the immune reaction from the blood site is under debate due to controversial findings.In bone marrow chimeric mice we were able to study the Heavy Duty Wheelchairs dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy.We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.